A conducting polymer with enhanced electronic stability applied in cardiac models
نویسندگان
چکیده
Electrically active constructs can have a beneficial effect on electroresponsive tissues, such as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered as components of these constructs because of their intrinsic electroactive and flexible nature. However, their clinical application has been largely hampered by their short operational time due to a decrease in their electronic properties. We show that, by immobilizing the dopant in the conductive scaffold, we can prevent its electric deterioration. We grew polyaniline (PANI) doped with phytic acid on the surface of a chitosan film. The strong chelation between phytic acid and chitosan led to a conductive patch with retained electroactivity, low surface resistivity (35.85 ± 9.40 kilohms per square), and oxidized form after 2 weeks of incubation in physiological medium. Ex vivo experiments revealed that the conductive nature of the patch has an immediate effect on the electrophysiology of the heart. Preliminary in vivo experiments showed that the conductive patch does not induce proarrhythmogenic activities in the heart. Our findings set the foundation for the design of electronically stable CP-based scaffolds. This provides a robust conductive system that could be used at the interface with electroresponsive tissue to better understand the interaction and effect of these materials on the electrophysiology of these tissues.
منابع مشابه
Synthesis & study of Polyethylene/Polyaniline/Montmorillonite ductile nano composites properties
Conducting polymers, because of their special properties, are used to introduce conductive polymeric composites. Also, clays have recently been used for preparation of polymer composites with enhanced mechanical and thermal properties. The aim of this work is to study the synergetic effect of the co-presence of conducting polyaniline and montmorillonite in the polyethylene matrix. Polyethylene ...
متن کاملSynthesis & study of Polyethylene/Polyaniline/Montmorillonite ductile nano composites properties
Conducting polymers, because of their special properties, are used to introduce conductive polymeric composites. Also, clays have recently been used for preparation of polymer composites with enhanced mechanical and thermal properties. The aim of this work is to study the synergetic effect of the co-presence of conducting polyaniline and montmorillonite in the polyethylene matrix. Polyethylene ...
متن کاملAn aptasensor based on electrosynthesized conducting polymers, Cu2O–carbon dots and biosynthesized gold nanoparticles, for monitoring carcinoembryonic antigen
Current work proposes an inimitable composite, with great electrical conductivity and quite enhanced surface area, (including conducting polymers (poly (cathechol)), Cu2O–carbon dots and green synthesized gold nanoparticles) for detecting acute carcinoembryonic antigen. At current work, the electropolymerization was offered instead of enzyme-catalyzed polymerization of poly (catechol). <b...
متن کاملCurrent Trends in Sensors Based on Conducting Polymer Nanomaterials
Conducting polymers represent an important class of functional organic materials for next-generation electronic and optical devices. Advances in nanotechnology allow for the fabrication of various conducting polymer nanomaterials through synthesis methods such as solid-phase template synthesis, molecular template synthesis, and template-free synthesis. Nanostructured conducting polymers featuri...
متن کاملConjugated Polymers for Neural Interfaces Prospects, possibilities and future challenges
Within the field of neuroprosthetics the possibility to use implanted electrodes for communication with the nervous system is explored. Much effort is put into the material aspects of the electrode implant to increase charge injection capacity, suppress foreign body response and build micro sized electrode arrays allowing close contact with neurons. Conducting polymers, in particular poly(3,4-e...
متن کامل